Potassium Carbonate → HCID 66942232, compound

Participants

Reaction Conditions

Reaction Steps

2,6-dimethoxyphenylboronic acid (1.0 g, 5.5 mmol), 6-Chloro-pyridine-3-sulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (555 mg, 1.8 mmol) and potassium carbonate (1.0 g, 7.3 mmol) were added to a degassed solution of tetrakis(triphenylphosphine) palladium (404 mg, 0.35 mmol) in toluol (12 ml) and ethanol (6 ml) and heated in a microwave reactor for 90 minutes at 90° C. The mixture was evaporated to dryness, suspended in 50 methanol and filtered off. The filtrate was evaporated to dryness and the residue was purified by flash chromatography (SiO2, heptane-ethyl acetate gradient) to return 639 mg of the title compound as an off-white solid, m/z=407 (ES+), 405 (ES−).

Provenance & Evidence