Hydrochloric Acid → 5-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(2-morpholin-4-ylethyl)thiophene-2-sulfonamide

関与物質

反応条件

反応手順

To N-[4-methyl-5-(5-{[(2-morpholin-4-ylethyl)amino]sulfonyl}-2-thienyl)-1,3-thiazol-2-yl]acetamide (9) (240 mg; 0.56 mmol; 1 eq) is added hydrochloric acid 1.25 M in EtOH (8.9 ml; 1.25 M; 11.2 mmol; 20 eq). The mixture is stirred overnight at 90° C. The mixture is cooled down to room temperature. The resulting precipitate is filtrated and rinsed with cold EtOH, affording Compound (6) as a yellowish solid (241.5 mg; 94%).

情報源と証拠