HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1360899Generated: October 31, 2026
Ethanol → 4-Methyl-5-[5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-amine
https://huagongshe.com/reaction/1360899
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ethanol | HCID 702 | — |
| Reactant | N-(4-methyl-5-{5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-yl)acetamide | HCID 11998679 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-Methyl-5-[5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-amine | HCID 11998908 | 124% |
Reaction Steps
N-(4-methyl-5-{5-[(4-methylpiperazin-1-yl)sulfonyl]-3-thienyl}-1,3-thiazol-2-yl)acetamide (34) (978.5 mg; 2.44 mmol; 1 eq) is dissolved in hydrochloric acid 1.25 M in EtOH (39.09 ml; 1.25 M; 48.9 mmol; 20 eq). The mixture is stirred overnight at 90° C. It is cooled down to RT, filtrated, affording Compound (43) as a white solid (1084.3 mg; 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07879888B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-4a4ef8151ada4cb2b353775c322a40cc |
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| Source note | uspto-grants-2011_02 |
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