Methanol → HCID 59682281, compound

HRID 1360958Notes

Reaction equation

HRID 1360958 reaction equation
[BH4-].[Na+].CO.[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][C:19](=[O:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:17])([F:16])[F:15])=[N:12][C:8]=2[CH:7]=1>O>[Cl:5][C:6]1[C:24]([Cl:25])=[CH:23][C:9]2[N:10]([CH2:18][CH:19]([OH:22])[CH2:20][CH3:21])[C:11]([CH2:13][C:14]([F:15])([F:16])[F:17])=[N:12][C:8]=2[CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 44430223HCID 44430223, compound

Product 1

HCID 59682281HCID 59682281, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium borohydride (11.16 mg, 0.2949 mmol) was added into methanol (5 mL). After the bubbling ceased, 1-[5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-benzoimidazol-1-yl]-butan-2-one (19170-168) (100 mg, 0.2949 mmol) was added. The resulting mixture was stirred at room temperature for 1 hour. The resulting mixture was poured into water and then extracted with EtOAc. The organic layer was dried over anhydrous MgSO4. The solvent was distilled out under reduced pressure to yield the title compound as an off-white solid.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over anhydrous MgSO4
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-8311d70ca3ac4a1abe6688da5bfc2974
Source dataset
uspto-grants-2011_02
Patent number
US07879895B2

Reaction notes

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