2-(Methylamino)ethanol → HCID 86611439, compound

Participants

Reaction Conditions

Reaction Steps

Finely powdered potassium carbonate (7.29 g, 52.2 mmol) was added to a solution of 5-bromo-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulphonylpyrazole (10.00 g, 19.3 mmol) in dry N,N-dimethylformamide (85 ml) and stirred for 1 hour at 20° C. 2-(Methylamino)ethanol (3.11 ml, 38.7 mmol) was then added and stirring continued for 2 hours at 20° C. The resulting mixture was poured into saturated ammonium chloride solution, extracted with ethyl acetate, and the organic layer washed with water and brine, dried (sodium sulfate), evaporated and purified by column chromatography eluting with hexane and ethyl acetate (2:1) to give 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-[N-(2-hydroxyethyl)-N-methylamino]-4-trifluoromethylsulfonylpyrazole as a fine white powder (5.65 g, yield 57%), 19F-NMR: −63.7, −78.4.

Provenance & Evidence