Thiazolidinedione → 5-[(2-ethyl-1H-indol-3-yl)methylidene]-1,3-thiazolidine-2,4-dione

HRID 1360991Notes

Reaction equation

[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[CH:12]=O)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2].[S:14]1[CH2:18][C:17](=[O:19])[NH:16][C:15]1=[O:20]>>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[CH:12]=[C:18]1[S:14][C:15](=[O:20])[NH:16][C:17]1=[O:19])=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 133838882-Ethyl-1H-indole-3-carbaldehyde

Product 1

HCID 1784378095-[(2-ethyl-1H-indol-3-yl)methylidene]-1,3-thiazolidine-2,4-dione

Procedure

2-Ethylindole-3-carbaldehyde (170 mg) was treated with thiazolidine-2,4-dione using the general procedure (C) to afford the title compound (50 mg).

Sources & evidence

ORD record: ord-e4c369776f6b49dcaaf6f925666203f0
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879893B2

Reaction notes

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