Potassium Hydroxide → HCID 59775205, compound

HRID 1361053Notes

Reaction equation

HRID 1361053 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([O:10]CC)=[O:9])=[CH:4][C:3]=1[CH3:15].[OH-].[K+]>O1CCOCC1>[F:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH3:15]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 59775200HCID 59775200, compound

Product 1

HCID 59775205HCID 59775205, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To the solution of ethyl 2-(4-fluoro-3-methylphenoxy)acetate (1.1 g, 5.1 mmol) in 10 mL dioxane was added 10 mL aqueous 5% KOH at 25° C. After being stirred for 30 min at room temperature the reaction was quenched by the addition of 12 mL of 1M aqueous HCl. The mixture was extracted ethyl acetate (2×40 mL) and the combined organic layers were washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

Workup

  1. customwas quenched by the addition of 12 mL of 1M aqueous HCl
  2. extractionThe mixture was extracted ethyl acetate (2×40 mL)
  3. washthe combined organic layers were washed with brine (2×30 mL)
  4. dry with materialThe solution was dried over Na2SO4
  5. concentrationbefore being concentrated under reduced pressure
  6. customThe crude product was used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-90a8401d79f44b1e9388804b642fe7b0
Source dataset
uspto-grants-2011_02
Patent number
US07879911B2

Reaction notes

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