反应详情

(S)-3-((R)-6-(4-fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)hex-4-enoyl)-4-isopropyloxazolidin-2-one (430 mg, 0.88 mmol) was dissolved into 4 mL benzene and to it added Wilkinson catalysis (81.0 mg, 0.088 mmol). The solution was saturated with H2 (stream of H2 bubbled through solution) and then stirred for 8 h at room temperature under an atmosphere of hydrogen balloon. The solvent was removed under reduced pressure and the product isolated by flash column chromatography eluting with 0% to 30% ethyl acetate/hexane to give 418 mg of the title compound as a colorless oil.

1. additionadded Wilkinson catalysis (81.0 mg, 0.088 mmol)
2. customThe solvent was removed under reduced pressure
3. customthe product isolated by flash column chromatography
4. washeluting with 0% to 30% ethyl acetate/hexane