HCID 59775172, compound → HCID 59775210, compound

HRID 1361063Notes

Reaction equation

HRID 1361063 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([O:12][CH3:13])=[O:11])=[CH:4][C:3]=1[CH3:14]>[Pd].CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][C:3]=1[CH3:14]

Participants

4

Reactant 1

HCID 59775172HCID 59775172, compound

Product 1

HCID 59775210HCID 59775210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(E)-Methyl 3-(4-fluoro-3-methylphenyl)acrylate (1.3 g, 6.7 mmol) was dissolved into 58 mL MeOH and to it added 10% Pd/C (750 mg). The solution was saturated with H2 and then stirred for 3 h at room temperature under an atmosphere of hydrogen balloon. The mixture was filtered through a bed of Celite and rinsed with ethyl acetate. The solvent was removed under reduced pressure and the crude product used directly in the next step without further purification.

Workup

  1. filtrationThe mixture was filtered through a bed of Celite
  2. washrinsed with ethyl acetate
  3. customThe solvent was removed under reduced pressure
  4. customthe crude product used directly in the next step without further purification

Sources & evidence

ORD record
ord-71d1f743b61148f8888cb799d721e31f
Source dataset
uspto-grants-2011_02
Patent number
US07879911B2

Reaction notes

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