Potassium Hydroxide → 4-Fluoro-3,5-dimethylphenol

Temperature

25 °C

To a solution of acetic acid 4-fluoro-3,5-dimethyl-phenyl ester in 10 mL dioxane was added 10 mL aqueous 5% KOH at 25° C. After being stirred for 30 min at 25° C., the reaction was quenched by the addition of 12 mL of 1M aqueous HCl. The mixture was extracted ethyl acetate (3×30 mL) and the combined organic layers were washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The product was isolated by silica gel chromatography to afford the title compound 987 mg, as a light yellow oil.

1. customthe reaction was quenched by the addition of 12 mL of 1M aqueous HCl
2. extractionThe mixture was extracted ethyl acetate (3×30 mL)
3. washthe combined organic layers were washed with brine (2×30 mL)
4. dry with materialThe solution was dried over Na2SO4
5. concentrationbefore being concentrated under reduced pressure
6. customThe product was isolated by silica gel chromatography

ORD record

ord-7842e221e7d540bf8e94e7a6a4a1dcee

Source dataset

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07879911B2