Methyl Ethyl Ketone → HCID 66971623, compound

Participants

Reaction Conditions

Reaction Steps

0.21 g (0.75 mmol) of potassium carbonate and then 0.85 ml (0.75 mmol) of benzyl bromide are added to a solution of 0.25 g (0.62 mmol) of methyl 3-{3-butoxy-4-[3-(4-hydroxy-3-methoxyphenyl)propyl]phenyl}propanoate (prepared according to Example 1d) in 25 ml of methyl ethyl ketone. The reaction mixture is heated at 70° C. for 24 hours and then cooled, diluted with ethyl acetate and washed with saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulfate, filtered and evaporated. The residue is purified by chromatography on a column of silica eluted with an 80/20 heptane/ethyl acetate mixture. 259 mg (93%) of methyl 3-{4-[3-(4-butoxy-3-methoxyphenyl)propyl]-3-propoxyphenyl}propanoate are obtained in the form of a colorless oil.

Provenance & Evidence