Water → HCID 86642708, compound

Participants

Reaction Steps

A solution of 400 mg (1 mmol) of methyl 3-{3-butoxy-4-[3-(4-hydroxy-3-methoxyphenyl)propyl]phenyl}propanoate, 170 μl (1.3 mmol) of butanesulfonyl chloride and 250 μl of triethylamine in 10 ml of tetrahydrofuran is stirred for 12 hours at room temperature. After addition of water and extraction with ethyl acetate, the organic phases are washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and evaporated. The residual oil is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 410 mg of methyl 3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propyl}-3-butoxyphenyl)propanoate are obtained in the form of a yellow oil.

Provenance & Evidence