Lithium Hydroxide → HCID 25123286, compound

Participants

Reaction Steps

ml (0.85 mmol) of aqueous 1N lithium hydroxide solution are added to a solution of 259 mg (0.6 mmol) of methyl 3-{3-butoxy-4-[3-(4-ethanesulfonyloxy-3-methoxyphenyl)propyl]phenyl}propanoate in 3 ml of tetrahydrofuran. The reaction mixture is stirred at room temperature for 12 hours, concentrated and then taken up in water, acidified by adding hydrochloric acid solution and then extracted with ethyl acetate ethyl. The organic phases are combined, washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and evaporated. After triturating in heptane, 208 mg (83%) of 3-{3-butoxy-4-[3-(4-ethanesulfonyloxy-3-methoxyphenyl)propyl]phenyl)propanoic acid are obtained in the form of white crystals with a melting point of 64° C.

Provenance & Evidence