HCID 86761272, compound → HCID 86761271, compound

Participants

Reaction Steps

11 g (20 mmol) of methyl(E)-3-(3-benzyloxy-4-{(E)-3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propenyl}phenyl)acrylate are dissolved in 100 ml of methanol and 1.1 g (10% massique) palladium-on-charcoal are then added. The reaction medium est placed under 1 atmosphere of hydrogen for 24 hours, and then filtered through Celite and rinsed with dichloromethane, and the filtration liquors are concentrated. The residue is purified by chromatography on a column of silica eluted with an 8/2 heptane/ethyl acetate mixture. 8 g (73%) of methyl 3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propyl}-3-hydroxyphenyl)propanoate are obtained.

Provenance & Evidence