Acetic Acid → HCID 86642713, compound

Participants

Reaction Steps

0.4 g (1 mmol) of lithium hydroxide monohydrate is added to a solution of 0.26 g (0.5 mmol) of corresponding methyl 3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propyl}-3-cyclopropylmethoxyphenyl)propanoate in 10 ml of a tetrahydrofuran/methanol/water mixture (5/1/1). The reaction medium is stirred at room temperature for 15 hours, treated with water, acidified to pH 4 with acetic acid and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and concentrated. The residue obtained is purified by chromatography on a column of silica eluted with a 97/3 dichloromethane/methanol mixture. 0.24 g (100%) of 3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propyl}-3-cyclopropylmethoxyphenyl)propanoic acid is obtained in the form of a colorless oil.

Provenance & Evidence