Water → Methyl 3-hydroxy-4-iodobenzoate

Participants

Reaction Steps

A solution of 140 g (530 mmol) of 3-hydroxy-4-iodobenzoic acid and 20.2 g (110 mmol) of para-toluenesulfonic acid in 900 ml of methanol is refluxed for 18 hours. After cooling, 700 ml of water are added and the medium is stirred for 18 hours. The product precipitates and is filtered off. After drying under vacuum at 50° C., 137 g (93%) of methyl 3-hydroxy-4-iodobenzoate are obtained in the form of a white solid.

Provenance & Evidence