HCID 86642715, compound → HCID 86642716, compound

Participants

Reaction Steps

78 mg (10% mass equivalent) of 10% palladium-on-charcoal are added to a solution of 780 mg (1.4 mmol) of methyl(E)-3-(2-benzyloxy-4-{(E)-3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propenyl}phenyl)acrylate in 8 ml of methanol. The reaction mixture is placed under an atmospheric pressure of hydrogen at room temperature for 16 hours and then filtered through Celite and rinsed with dichloromethane. The solvents are evaporated off and the residue is then purified by chromatography on a column of silica eluted with a 60/40 heptane/ethyl acetate mixture. 610 mg (94%) of methyl 3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxyphenyl]propyl}-2-hydroxyphenyl)propanoate are obtained in the form of a colorless oil.

Provenance & Evidence