1-(2-(Dimethylamino)ethyl)piperazine → HCID 59758725, compound

HRID 1361104Notes

Reaction equation

HRID 1361104 reaction equation
[CH3:1][N:2]([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.[CH3:12][Si:13]([CH3:28])([CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[CH2:14][CH2:15][CH2:16][O:17][CH2:18][CH:19]1[CH2:21][O:20]1>C(O)C>[CH3:1][N:2]([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:21][CH:19]([OH:20])[CH2:18][O:17][CH2:16][CH2:15][CH2:14][Si:13]([CH3:12])([CH3:28])[CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 27362291-(2-(Dimethylamino)ethyl)piperazineHCID 597587042-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane

Product 1

HCID 59758725HCID 59758725, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Conditions

Temperature
70 °C

Procedure

Dimethyl-(2-piperazin-1-yl-ethyl)-amine (1.14 g; 7.28 mMol) and 40 mL of ethanol were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 70° C. 2-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane 8 (2 g; 7.28 mMol) mixed with 10 g ethanol was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 70° C. for an additional 4 hours. Ethanol was stripped off on the rotovap. The mixture was distilled under vacuum to remove impurities.

Workup

  1. customequipped with a magnetic stirrer
  2. customwas placed in an addition funnel
  3. additionadded dropwise to the flask
  4. stirringThe mixture was stirred
  5. temperaturemaintained at 70° C. for an additional 4 hours
  6. distillationThe mixture was distilled under vacuum
  7. customto remove impurities

Sources & evidence

ORD record
ord-2a21650e598d4024ba925e071a568fa5
Source dataset
uspto-grants-2011_02
Patent number
US07879916B2

Reaction notes

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