Dimethylamine → HCID 59758724, compound

HRID 1361111Notes

Reaction equation

HRID 1361111 reaction equation
[CH3:1][NH:2][CH3:3].C(O)C.[CH3:7][Si:8]([CH3:23])([CH2:17][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[CH2:9][CH2:10][CH2:11][O:12][CH2:13][CH:14]1[CH2:16][O:15]1>O>[CH3:1][N:2]([CH3:3])[CH2:16][CH:14]([OH:15])[CH2:13][O:12][CH2:11][CH2:10][CH2:9][Si:8]([CH3:23])([CH3:7])[CH2:17][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20]

Participants

5

Reactant 3

HCID 674Dimethylamine2×HCID 702Ethanol3×HCID 597587042-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane

Product 1

HCID 59758724HCID 59758724, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Aqueous dimethylamine (25%; 10 g, dimethyl amine 55 mMol) and 40 mL of ethanol were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 50° C. 2-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane 8 (2 g; 7.28 mMol) mixed with 10 g ethanol was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 50° C. for an additional 8 hours. Ethanol, water and excess dimethyl amine were stripped off on the rotovap. The mixture was distilled under vacuum to remove impurities.

Workup

  1. customequipped with a magnetic stirrer
  2. customwas placed in an addition funnel
  3. additionadded dropwise to the flask
  4. stirringThe mixture was stirred
  5. temperaturemaintained at 50° C. for an additional 8 hours
  6. distillationThe mixture was distilled under vacuum
  7. customto remove impurities

Sources & evidence

ORD record
ord-a901e36476984e6fb0f4ffea67d59056
Source dataset
uspto-grants-2011_02
Patent number
US07879916B2

Reaction notes

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