Diisopropylamine → HCID 59758722, compound

HRID 1361113Notes

Reaction equation

HRID 1361113 reaction equation
[CH:1]([NH:4][CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[CH3:8][Si:9]([CH3:24])([CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])[CH2:10][CH2:11][CH2:12][O:13][CH2:14][CH:15]1[CH2:17][O:16]1>C(O)C>[CH:1]([N:4]([CH:5]([CH3:7])[CH3:6])[CH2:17][CH:15]([OH:16])[CH2:14][O:13][CH2:12][CH2:11][CH2:10][Si:9]([CH3:8])([CH3:24])[CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 7912Diisopropylamine2×HCID 597587042-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane

Product 1

HCID 59758722HCID 59758722, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Conditions

Temperature
60 °C

Procedure

Diisopropylamine (3.68 g, 36.4 mMol) and 40 mL of ethanol were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 60° C. 2-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane 8 (2 g; 7.28 mMol) mixed with 10 g ethanol was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 60° C. for an additional 8 hours. Ethanol and diisopropylamine were stripped off on the rotovap. The mixture was distilled under vacuum to remove impurities.

Workup

  1. customequipped with a magnetic stirrer
  2. customwas placed in an addition funnel
  3. additionadded dropwise to the flask
  4. stirringThe mixture was stirred
  5. temperaturemaintained at 60° C. for an additional 8 hours
  6. distillationThe mixture was distilled under vacuum
  7. customto remove impurities

Sources & evidence

ORD record
ord-fb6f6d71ac574c70958d16236e5752a4
Source dataset
uspto-grants-2011_02
Patent number
US07879916B2

Reaction notes

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