反应详情

温度

60 °C

A solution of [(S)-1-(2-carbamoyl-pyridin-4-yl)-propyl]carbamic acid tert-butyl ester (1 g, 3.58 mmol) in MeOH (16.6 mL) and glacial acetic acid (3.3 mL) was added to a flask containing 10% palladium on carbon (0.38 g, 0.36 mmol) under nitrogen. The reaction was stirred at 60° C. under hydrogen at 400 psi using a Biotage Endeavour Argonaut instrument. After 20 hours, the reaction was filtered and concentrated. The crude material was diluted with EtOAc (100 mL), washed with saturated sodium carbonate solution (20 mL), brine, dried over sodium sulfate, filtered and concentrated to afford [(S)-1-(2-carbamoyl-piperidin-4-yl)-propyl]carbamic acid tert-butyl ester as a white solid.

1. filtrationthe reaction was filtered
2. concentrationconcentrated
3. additionThe crude material was diluted with EtOAc (100 mL)
4. washwashed with saturated sodium carbonate solution (20 mL), brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated