反应详情

To a solution of 4-Trifluoromethylcyclohexanol (4.5 g, 26.7 mmol) in DCM (100 ml) was added Dess-Martin periodinane (13.6 g, 32 mmol), and stirred at rt for 2 h. After the reaction finished, the reaction mixture was concentrated in vacuo, sodium thiosulfate aqueous solution and diethylether were added and stirred at rt for 30 min, and extracted with diethylether. The organic layer was dried over MgSO4, concentrated in vacuo at rt to give the title compound (4.2 g, 94.6%).

1. concentrationthe reaction mixture was concentrated in vacuo, sodium thiosulfate aqueous solution and diethylether
2. additionwere added
3. stirringstirred at rt for 30 min
4. extractionextracted with diethylether
5. dry with materialThe organic layer was dried over MgSO4
6. concentrationconcentrated in vacuo at rt