Hydrochloric Acid → 3-(Acetyloxy)-2,2-dimethylpropanoic acid

Participants

Reaction Conditions

Reaction Steps

2,2-Dimethyl-3-hydroxypropionic acid (11.8 g, 100 mmol) was dissolved in pyridine (30 mL), and the reaction solution was cooled to 0° C. Acetyl chloride (11.8 g, 15.0 mmol) was slowed added dropwise, the temperature was increased to rt, and the reaction solution was stirred at rt for 3 h. After the reaction finished, 1N HCl (30 mL) was added, pH adjusted to 3-4, the reaction mixture was extracted with EtOAc. The organic extracts were washed with 1N HCl for 4-5 times, dried over MgSO4, concentrated in vacuo to give the title compound (15.2 g, 95.0%).

Provenance & Evidence