N-Methylethylamine → HCID 66971216, compound

HRID 1361300Notes

Reaction equation

[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:24]2[CH2:29][CH2:28][C:27]([CH3:31])([CH3:30])[CH2:26][CH2:25]2)[C:17]([C@@H:19]2[CH2:23][CH2:22][CH2:21][O:20]2)=[O:18])[CH2:13][C@H:9]1[C:10]([OH:12])=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:32][NH:33][CH2:34][CH3:35]>>[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:24]2[CH2:29][CH2:28][C:27]([CH3:31])([CH3:30])[CH2:26][CH2:25]2)[C:17]([C@@H:19]2[CH2:23][CH2:22][CH2:21][O:20]2)=[O:18])[CH2:13][C@H:9]1[C:10]([N:33]([CH2:34][CH3:35])[CH3:32])=[O:12])([O:3][C:4]([CH3:7])([CH3:5])[CH3:6])=[O:2]

Participants

Reactant 2

HCID 12219N-Methylethylamine

HCID 66971234HCID 66971234, compound

Product 1

HCID 66971216HCID 66971216, compound

Procedure

The title compound was prepared according to the procedure described in Step D of Example A1, using (4S)-1-BOC-4-{(4,4-dimethylcyclohexyl)[(2S)-tetrahydrofuran-2-ylcarbonyl]amino}-L-proline (0.96 g, 2.2 mmol) prepared in Step B and commercially available N-methylethylamine (0.92 g, 93%).

Sources & evidence

ORD record: ord-669ea4a12e5e4c47a9e8d4297b575ae6
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

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