Ethylamine → HCID 66971258, compound

HRID 1361301Notes

Reaction equation

[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:24]2[CH2:29][CH2:28][C:27]([CH3:31])([CH3:30])[CH2:26][CH2:25]2)[C:17]([C@@H:19]2[CH2:23][CH2:22][CH2:21][O:20]2)=[O:18])[CH2:13][C@H:9]1[C:10](O)=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:32]([NH2:34])[CH3:33]>>[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:24]2[CH2:29][CH2:28][C:27]([CH3:30])([CH3:31])[CH2:26][CH2:25]2)[C:17]([C@@H:19]2[CH2:23][CH2:22][CH2:21][O:20]2)=[O:18])[CH2:13][C@H:9]1[C:10]([NH:34][CH2:32][CH3:33])=[O:11])([O:3][C:4]([CH3:7])([CH3:5])[CH3:6])=[O:2]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 66971234HCID 66971234, compound

Product 1

HCID 66971258HCID 66971258, compound

Procedure

The title compound was prepared according to the procedure described in Step D of Example A1, using (4S)-1-BOC-4-{(4,4-dimethylcyclohexyl)[(2S)-tetrahydrofuran-2-ylcarbonyl]amino}-L-proline (0.96 g, 2.2 mmol) prepared in Step B of Example A2 and commercially available ethylamine (0.95 g, 93%).

Sources & evidence

ORD record: ord-94cfb729c3134bb881e115fec411c0d0
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

Loading…