HCID 66971258, compound → HCID 66971009, compound

HRID 1361302Notes

Reaction equation

HRID 1361302 reaction equation
C([N:8]1[CH2:12][C@@H:11]([N:13]([CH:21]2[CH2:26][CH2:25][C:24]([CH3:28])([CH3:27])[CH2:23][CH2:22]2)[C:14]([C@@H:16]2[CH2:20][CH2:19][CH2:18][O:17]2)=[O:15])[CH2:10][C@H:9]1[C:29]([NH:31][CH2:32][CH3:33])=[O:30])(OC(C)(C)C)=O>C(Cl)Cl>[CH3:28][C:24]1([CH3:27])[CH2:25][CH2:26][CH:21]([N:13]([C:14]([CH:16]2[CH2:20][CH2:19][CH2:18][O:17]2)=[O:15])[C@@H:11]2[CH2:12][NH:8][C@H:9]([C:29]([NH:31][CH2:32][CH3:33])=[O:30])[CH2:10]2)[CH2:22][CH2:23]1

Participants

3

Reactant 1

HCID 66971258HCID 66971258, compound

Product 1

HCID 66971009HCID 66971009, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 1-BOC-(2S,4S)-4-{(4,4-dimethylcyclohexyl)[(2S)-tetrahydrofuran-2-ylcarbonyl]amino}-2-[(ethylamino)carbonyl)pyrrolidine (0.95 g, 2.0 mmol) prepared in Step A in DCM (1□) was added dropwise 4M HCl (1□). The reaction mixture was stirred at rt for 1 h, and concentrated in vacuo. The residue was concentrated in vacuo to give the title compound (730 mg, 99.9%).

Workup

  1. concentrationconcentrated in vacuo
  2. concentrationThe residue was concentrated in vacuo

Sources & evidence

ORD record
ord-4ba76348d6594093a8a0758398372f16
Source dataset
uspto-grants-2011_02
Patent number
US07879852B2

Reaction notes

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