Ethylamine → HCID 66971150, compound

HRID 1361305Notes

Reaction equation

[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:23]2[CH2:28][CH2:27][C:26]([F:30])([F:29])[CH2:25][CH2:24]2)[C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:13][C@H:9]1[C:10]([OH:12])=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:31]([NH2:33])[CH3:32]>>[C:1]([N:8]1[CH2:15][C@@H:14]([N:16]([CH:23]2[CH2:28][CH2:27][C:26]([F:30])([F:29])[CH2:25][CH2:24]2)[C:17](=[O:22])[C:18]([CH3:20])([CH3:19])[CH3:21])[CH2:13][C@H:9]1[C:10]([NH:33][CH2:31][CH3:32])=[O:12])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 66971184HCID 66971184, compound

Product 1

HCID 66971150HCID 66971150, compound

Procedure

The title compound was prepared according to the procedure described in Step D of Example A1 using (4S)-1-BOC-4-[(4,4-difluorocyclohexyl)(2,2-dimethylpropanoyl)amino]-L-proline (0.95 g, 2.2 mmol) prepared in Step C of Example A5 and commercially available ethylamine (0.93 g, 93%).

Sources & evidence

ORD record: ord-87decc805f34460ea1c9d289899782c6
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

Loading…