HCID 66971046, compound → HCID 57990691, compound

HRID 1361308Notes

Reaction equation

[C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([N:13]([CH:21]2[CH2:26][CH2:25][C:24]([CH3:28])([CH3:27])[CH2:23][CH2:22]2)[C:14](=[O:20])[C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:9]1)(OC(C)(C)C)=[O:2].[C:29]([N:33]1[CH2:37][C@@H:36]([C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=2)[C@H:35](C(O)=O)[CH2:34]1)([CH3:32])([CH3:31])[CH3:30]>>[C:29]([N:33]1[CH2:37][C@@H:36]([C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=2)[C@H:35]([C:1]([N:8]2[CH2:12][CH2:11][C@H:10]([N:13]([CH:21]3[CH2:26][CH2:25][C:24]([CH3:27])([CH3:28])[CH2:23][CH2:22]3)[C:14](=[O:20])[C:15]([CH3:18])([CH3:19])[CH2:16][OH:17])[CH2:9]2)=[O:2])[CH2:34]1)([CH3:32])([CH3:30])[CH3:31]

Participants

Reactant 2

HCID 66971046HCID 66971046, compound

HCID 66971267HCID 66971267, compound

Product 1

HCID 57990691HCID 57990691, compound

Procedure

The title compound was prepared according to the procedure described in Step F-G of Example A1, using N-(4,4-dimethylcyclohexyl)-3-hydroxy-2,2-dimethyl-N-[(3S)-pyrrolidine-3-yl]propaneamide (500 mg, 1.21 mmol) prepared in Step B and (3S,4R)-1-t-butyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-2 (672 mg, 91.9%).

Sources & evidence

ORD record: ord-4e110436e56141c48757053451971875
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

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