Lithium borohydride → HCID 66970916, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-BOC-2-methyl-(2S,4S)-4-[(4,4-dimethylcyclohexyl)(2,2-dimethylpropanoyl)amino]pyrrolidine-2-carboxylate (1.18 g, 2.71 mmol) prepared in Step B of Example A1 in THF (10 ml) was added LiBH4 (177 mg, 8.13 mmol). The solution was stirred at 70° C. for 2 h, concentrated in vacuo, and extracted with EtOAc. The organic extracts were washed with a saturated NaHCO3 aqueous solution and brine, dried over MgSO4, and concentrated in vacuo to give the title compound (0.88 g, 81%).

Provenance & Evidence