Lithium borohydride → HCID 66970919, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of BOC-(2R,4S)-4-[(4,4-dimethylcyclohexyl)(2,2-dimethylpropanoyl)amino]-2-{[(methylsulfonyl)oxy]methyl}pyrrolidine (580 mg, 1.19 mmol) prepared in Step B in THF (5 ml) was added dropwise LiBH4 (77 mg, 3.57 mmol) at 70° C. The solution was stirred at 70° C. for 5 h, concentrated in vacuo, and extracted with EtOAC. The organic extracts were washed with a saturated NaHCO3 aqueous solution and brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by column chromatography (eluent: EtOAc:Hex=1/4) to give the title compound (258 mg, 53%).

Provenance & Evidence