HCID 66971046, compound → HCID 86636649, compound

HRID 1361325Notes

Reaction equation

[CH3:1][C:2]1([CH3:22])[CH2:7][CH2:6][CH:5]([N:8]([C@H:17]2[CH2:21][CH2:20][NH:19][CH2:18]2)[C:9](=[O:16])[C:10]([CH3:15])([CH3:14])[C:11](=[O:13])[CH3:12])[CH2:4][CH2:3]1.[C:23]([N:27]1[CH2:31][C@@H:30]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)[C@H:29]([C:39](O)=[O:40])[CH2:28]1)([CH3:26])([CH3:25])[CH3:24]>>[ClH:38].[C:23]([N:27]1[CH2:31][C@@H:30]([C:32]2[CH:33]=[CH:34][C:35]([Cl:38])=[CH:36][CH:37]=2)[C@H:29]([C:39]([N:19]2[CH2:20][CH2:21][C@H:17]([N:8]([CH:5]3[CH2:6][CH2:7][C:2]([CH3:22])([CH3:1])[CH2:3][CH2:4]3)[C:9](=[O:16])[C:10]([CH3:14])([CH3:15])[C:11](=[O:13])[CH3:12])[CH2:18]2)=[O:40])[CH2:28]1)([CH3:26])([CH3:25])[CH3:24]

Participants

Reactant 2

HCID 66971046HCID 66971046, compound

HCID 86636651HCID 86636651, compound

Product 1

HCID 86636649HCID 86636649, compound

Procedure

The title compound was prepared according to the procedure described in Step F, G of Example A1, using N-(4,4-dimethylcyclohexyl)-2,2-dimethyl-3-oxo-N-[(3S)-pyrrolidine-3-yl]butaneamide (50 mg, 0.11 mmol) prepared in Step B and (3S,4R)-1-t-butyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-2 (56 mg, 89%).

Sources & evidence

ORD record: ord-733ca98143124e93b4da8a74c79e87af
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

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