HCID 66970964, compound → HCID 66971131, compound

HRID 1361327Notes

Reaction equation

[CH3:1][C:2]1([CH3:23])[CH2:7][CH2:6][CH:5]([N:8]([C@H:18]2[CH2:22][CH2:21][NH:20][CH2:19]2)[C:9](=[O:17])[C:10]([CH3:16])([CH3:15])[C:11]([OH:14])([CH3:13])[CH3:12])[CH2:4][CH2:3]1.[C:24]([N:28]1[CH2:32][C@@H:31]([C:33]2[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=2)[C@H:30]([C:40](O)=[O:41])[CH2:29]1)([CH3:27])([CH3:26])[CH3:25]>>[ClH:39].[C:24]([N:28]1[CH2:32][C@@H:31]([C:33]2[CH:34]=[CH:35][C:36]([Cl:39])=[CH:37][CH:38]=2)[C@H:30]([C:40]([N:20]2[CH2:21][CH2:22][C@H:18]([N:8]([CH:5]3[CH2:6][CH2:7][C:2]([CH3:23])([CH3:1])[CH2:3][CH2:4]3)[C:9](=[O:17])[C:10]([CH3:15])([CH3:16])[C:11]([OH:14])([CH3:12])[CH3:13])[CH2:19]2)=[O:41])[CH2:29]1)([CH3:27])([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 66970964HCID 66970964, compound

HCID 66971046HCID 66971046, compound

Product 1

HCID 66971131HCID 66971131, compound

Procedure

The title compound was prepared according to the procedure described in Step F, G of Example A1, using N-(4,4-dimethylcyclohexyl)-3-hydroxy-2,2,3-trimethyl-N-[(3S)-pyrrolidine-3-yl]butaneamide (62 mg, 0.19 mmol) prepared in Step B and (3S,4R)-1-t-butyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-2 (99 mg, 89%).

Sources & evidence

ORD record: ord-99ca1fba369d4883be879b64600195a3
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

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