HCID 66971046, compound → HCID 66971279, compound

HRID 1361329Notes

Reaction equation

HRID 1361329 reaction equation
[CH3:1][C:2]1([CH3:21])[CH2:7][CH2:6][CH:5]([N:8]([C@H:16]2[CH2:20][CH2:19][NH:18][CH2:17]2)[C:9](=[O:15])[C:10]([CH3:14])([CH3:13])[CH2:11][F:12])[CH2:4][CH2:3]1.[C:22]([N:26]1[CH2:30][C@@H:29]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[C@H:28]([C:38](O)=[O:39])[CH2:27]1)([CH3:25])([CH3:24])[CH3:23]>>[ClH:37].[C:22]([N:26]1[CH2:30][C@@H:29]([C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)[C@H:28]([C:38]([N:18]2[CH2:19][CH2:20][C@H:16]([N:8]([CH:5]3[CH2:6][CH2:7][C:2]([CH3:21])([CH3:1])[CH2:3][CH2:4]3)[C:9](=[O:15])[C:10]([CH3:13])([CH3:14])[CH2:11][F:12])[CH2:17]2)=[O:39])[CH2:27]1)([CH3:25])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 66971046HCID 66971046, compoundHCID 66971256HCID 66971256, compound

Product 1

HCID 66971279HCID 66971279, compound

Procedure

The title compound was prepared according to the procedure described in Step F, G of Example A1, using N-(4,4-dimethylcyclohexyl)-3-fluoro-2,2-dimethyl-N-[(3S)-pyrrolidine-3-yl]propaneamide (100 mg, 0.47 mmol) prepared in Step B and (3S,4R)-1-t-butyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-2 (230 mg, 89%).

Sources & evidence

ORD record
ord-368858b229a549c486f86922c2069035
Source dataset
uspto-grants-2011_02
Patent number
US07879852B2

Reaction notes

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