HCID 66971046, compound → HCID 86636653, compound

HRID 1361331Notes

Reaction equation

[CH3:1][N:2]([CH3:28])[CH2:3][C:4]([CH3:27])([CH3:26])[C:5]([N:7]([CH:18]1[CH2:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][CH2:19]1)[C@@H:8]1[CH2:12][NH:11][C@H:10]([C:13]([N:15]([CH3:17])[CH3:16])=[O:14])[CH2:9]1)=[O:6].[C:29]([N:33]1[CH2:37][C@@H:36]([C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=2)[C@H:35]([C:45](O)=[O:46])[CH2:34]1)([CH3:32])([CH3:31])[CH3:30]>>[ClH:44].[C:29]([N:33]1[CH2:37][C@@H:36]([C:38]2[CH:39]=[CH:40][C:41]([Cl:44])=[CH:42][CH:43]=2)[C@H:35]([C:45]([N:11]2[CH2:12][C@@H:8]([N:7]([C:5](=[O:6])[C:4]([CH3:27])([CH3:26])[CH2:3][N:2]([CH3:1])[CH3:28])[CH:18]3[CH2:23][CH2:22][C:21]([CH3:24])([CH3:25])[CH2:20][CH2:19]3)[CH2:9][C@H:10]2[C:13]([N:15]([CH3:16])[CH3:17])=[O:14])=[O:46])[CH2:34]1)([CH3:32])([CH3:31])[CH3:30]

Participants

Reactant 2

HCID 66971046HCID 66971046, compound

HCID 66971259HCID 66971259, compound

Product 1

HCID 86636653HCID 86636653, compound

Procedure

The title compound was prepared according to the procedure described in Step F, G of Example A1, using (4S)-4-{[3-(dimethylamino)-2,2-dimethylpropanoyl](4,4-dimethylcyclohexyl)amino)}-N,N-dimethyl-L-prolineamide (82 mg, 0.18 mmol) prepared in Step B and (3S,4R)-1-t-butyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-2 (105 mg, 89%).

Sources & evidence

ORD record: ord-e71172e6fdfe40a3b156438513daa9f0
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07879852B2

Reaction notes

Loading…