Tetrahydro-4H-pyran-4-one → HCID 86636658, compound

Participants

Reaction Steps

(4S)-4-[(4,4-dimethylcyclohexyl)(tetrahydrofuran-2-ylcarbonyl)amino]-N-ethyl-N-m ethyl-L-prolineamide (100 mg, 0.26 mmol) prepared in Step D of Example A2 and (3S,4R)-1-(tert-butoxycarbonyl)-4-(4-chlorophenyl)pyrrolidine-3-carboxylic acid prepared in Preparation Example A9-9 were reacted according to the procedure described in Step F of Example A1, and then according to that in Step E of Example A1. This compound was reacted with tetrahydro-4H-pyran-4-one via reductive amination as described in Step A of Example A1, and purified by HPLC. This TFA salt of the compound was treated according to the procedure described in Step G of Example A1 to give the title compound (139 mg, 80%).

Provenance & Evidence