Triethylamine → HCID 58182720, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-(5-(2-methoxyphenyl)-1,2,4-thiadiazol-3-yl)piperazine (80 mg, 0.29 mmol) and triethylamine (61 μL, 0.43 mmol) in CH2Cl2 (0.5 mL) at 0° C. was added isobutyl chloroformate (59 mg, 0.43 mmol) in CH2Cl2 (0.5 mL). The reaction mixture was stirred at 0° C. for 1 h, diluted with water, and extracted with CH2Cl2. The combined extracts were washed with water, dried over Na2SO4, and concentrated under reduced pressure to yield isobutyl 4-(5-(2-methoxyphenyl)-1,2,4-thiadiazol-3-yl)piperazine-1-carboxylate. LC/MS: m/z 377.5 (M+H)+ at 3.81 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

Provenance & Evidence