HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → (4-Chloro-phenyl)-(2-chloro-6-trifluoromethyl-pyrimidin-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,4-Dichloro-6-(trifluoromethyl)pyrimidine | HCID 334203 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | (4-Chloro-phenyl)-(2-chloro-6-trifluoromethyl-pyrimidin-4-yl)-amine | HCID 58451036 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of 2,4-dichloro-6-trifluoromethyl-pyrimidine (90 mg, 0.41 mmol) in n-butanol (1 mL), was added 4-chloro-phenylamine (52 mg, 0.416 mmol) and DIPEA (72 uL, 0.416). The mixture was stirred at 100° C. for overnight. The LC-MS showed the desired product mass [MS:(ESI), M/Z, 308 (M+1). Retention time: 2.70 min (FA-polar)]. This intermediate was used in situ without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07880002B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-3388ecdf38eb4ac7a16ac0e3efc34a40 |
| Source note | uspto-grants-2011_02 |