Diisopropylethylamine → 4-(4-Chloro-phenyl)-1-[1-(5,6-dimethyl-2-trifluoromethyl-pyrimidin-4-yl)-4-hydroxy-pyrrolidin-3-yl]-piperidin-4-ol

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Reaction Steps

The title compound was prepared following general procedures described above from trans-4-(4-chloro-phenyl)-1-(4-hydroxy-pyrrolidin-3-yl)-piperidin-4-ol hydrochloride and 4-chloro-5,6-dimethyl-2-trifluoromethyl-pyrimidine in the presence of diisopropylethylamine and DMF. 1H-NMR (300 MHz, DMSO): δ 1.58 (2 H, m), 1.89 (2 H, m), 2.40 (3 H, s), 2.60 (3 H, m), 2.95 (2 H, m), 3.32 (1 H, m), 3.44 (1 H, m), 3.80 (2 H, m), 4.32 (1 H, m), 4.90 (1 H, s), 5.20 (1 H, d), 6.92 (1 H, s), 7.42 (4 H, dd). Retention Time (LC, method, AA standard): 1.75 min. MS (M+H+): 457

Provenance & Evidence