2-Thiazolamine, 5-bromo- → 3-isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)benzamide

HRID 1361532Notes

Reaction equation

HRID 1361532 reaction equation
[Br:1][C:2]1[S:6][C:5]([NH2:7])=[N:4][CH:3]=1.[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=1)[C:15](O)=[O:16])([CH3:10])[CH3:9]>>[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=1)[C:15]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:16])([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 436002-Thiazolamine, 5-bromo-HCID 669698623-Isopropyloxy-5-phenoxybenzoic acid

Product 1

HCID 866323843-isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)benzamideYield 82%

Procedure

3-Isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)-benzamide (1.1 g, 82%) was prepared from 5-bromo-2-aminothiazole (830 mg, 4.6 mmol) and 3-isopropyloxy-5-phenoxybenzoic acid (835 mg, 3.1 mmol) following the general procedure A.

Sources & evidence

ORD record
ord-d1ab13ecd0a642caa0b17ac2d0d89c69
Source dataset
uspto-grants-2011_02
Patent number
US07880012B2

Reaction notes

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