1-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine → 2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

Participants

Reaction Steps

To 1-Methyl-4-(2-nitro-4-trifluoromethyl-phenyl)-piperazine (1.46 g, 5.05 mmol) in dry MeOH (50 mL) was added Pd/C (10%, 535 mg). H2 gas was bubbled through the solution at room temperature overnight with vigorous stirring. The reaction mixture was filtered through celite to provide, after concentration, the desired product as a white solid. MS (M+H)+=260; Calc'd 259.28 for C12H16F3N3.

Provenance & Evidence