1,3-Propanediamine, N1,N1,N3-trimethyl- → HCID 16109013, compound

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Reaction Steps

To a round bottom flask at 0° C. was added 4-Bromo-1-fluoro-2-nitrobenzene (10 g, 45 mmol) and N,N,N′-Trimethyl-propane-1,3-diamine (6.99 ml, 47.7 mmol). The reaction was allowed to warm to RT and stirred for 16 h. The reaction was extracted into EtOAc, washed once with saturated aqueous NaHCO3, twice with water, and then dried over Mg2SO4. The organic layer was filtered and concentrated to yield the title compound as a bright orange solid. MS (M+H+)=316, 318; Calc'd for C12H18BrN3O2=316.19.

Provenance & Evidence