HCID 66970340, compound → HCID 19627074, compound

HRID 1361594Notes

Reaction equation

HRID 1361594 reaction equation
[N+:1]([C:4]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([O-])=O>CO.[Pd]>[N:9]1([CH2:8][CH2:7][O:6][C:5]2[CH:14]=[CH:15][C:16]([C:18]([F:20])([F:21])[F:19])=[CH:17][C:4]=2[NH2:1])[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 66970340HCID 66970340, compound

Product 1

HCID 19627074HCID 19627074, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-[2-(2-Nitro-4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine (1.70 g, 5.59 mmol) in dry MeOH (56 mL) was added Pd/C (10%, 350 mg). H2 gas was bubbled through the solution, which was then stirred vigorously under an atmosphere of H2. After completion of the reaction by LCMS, the mixture was filtered through celite and concentrated to affod the desired product as a yellow/orange oil. MS (M+H)+=275; Calc'd 274.29 for C13H17F3N2O.

Workup

  1. customH2 gas was bubbled through the solution, which
  2. customAfter completion of the reaction by LCMS
  3. filtrationthe mixture was filtered through celite and
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8a397fc7526643f4bd6e0cd97f024eb8
Source dataset
uspto-grants-2011_02
Patent number
US07880000B2

Reaction notes

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