HCID 86602590, compound → HCID 86602589, compound

HRID 1361602Notes

Reaction equation

HRID 1361602 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([S:14]([CH:17]2[CH2:22][N:21]([CH:23]=[O:24])[CH2:20][CH2:19][O:18]2)(=[O:16])=[O:15])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([S:14]([CH:17]2[CH2:22][N:21]([CH:23]=[O:24])[CH2:20][CH2:19][O:18]2)(=[O:16])=[O:15])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[CH:9]=1

Participants

4

Reactant 1

HCID 86602590HCID 86602590, compound

Product 1

HCID 86602589HCID 86602589, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To an argon purged solution of (3-nitro-5-(trifluoromethyl)phenyl)-(sulfonylmorpholino) methanone (658 mg, 1.87 mmol) in EtOH (20 mL) was added Pd/C (198 mg, 0.187 mmol, 10%). The resulting mixture was allowed to stir under an atmosphere of hydrogen gas for 3 days. The reaction was purged with argon, filtered through Celite and concentrated under reduced pressure to afford (3-amino-5-(trifluoromethyl)phenyl)-(sulfonylmorpholino)methanone which was used without further purification. MS m/z=323 [M+H]+. Calc'd for C12H13F3N2O3S: 322.

Workup

  1. customThe reaction was purged with argon
  2. filtrationfiltered through Celite
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-78105774a62648f0af87e7c82f5e5b3e
Source dataset
uspto-grants-2011_02
Patent number
US07880000B2

Reaction notes

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