HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine; trifluoroacetic acid → 2,3-dichloro-N-(2-fluoro-4-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine; trifluoroacetic acid | HCID 12210277 | — |
| Reactant | 4-(2-Chloropyridin-3-yl)pyrimidine | HCID 16108974 | — |
| Reactant | N-(4-amino-2-fluorophenyl)-2,3-dichlorobenzenesulfonamide | HCID 66970470 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 2,3-dichloro-N-(2-fluoro-4-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzenesulfonamide | HCID 58587849 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To N-(4-amino-2-fluorophenyl)-2,3-dichlorobenzenesulfonamide (0.150 g, 0.45 mmol) and 4-(2-chloropyridin-3-yl)pyrimidine (0.086 g, 0.45 mmol) was added NEt3.TFA. The mixture was heated at 100° C. CH2Cl2/MeOH was added, producing a yellow precipitate, which was filtered. Trituration with a further portion of CH2Cl2/MeOH, followed by filtration, afforded 2,3-dichloro-N-(2-fluoro-4-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzenesulfonamide as an orange solid. MS m/z=491 [M+H]+. Calc'd for C21H14Cl2FN5O2S: 490.35.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07880000B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-15717b2cf1064cb9924ca23edfef2ab4 |
| Source note | uspto-grants-2011_02 |