Morpholine → N-[4-(2-Furyl)-5-morpholinothiazol-2-yl]-2-morpholinopyridine-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	2-Chloro-N-[4-(2-furyl)-5-morpholinothiazol-2-yl]pyridine-4-carboxamide	HCID 23144123	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	N-[4-(2-Furyl)-5-morpholinothiazol-2-yl]-2-morpholinopyridine-4-carboxamide	HCID 23144302	27%

Reaction Conditions

Temperature	150 °C

Reaction Steps

Compound 39 (391 mg, 1.00 mmol) was dissolved in NMP (10 mL), morpholine (1.05 mL, 12.0 mmol) was added thereto, followed by stirring at 150° C. for 8 hours. The reaction mixture was purified through silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3) to afford the entitled Compound 40 (118 mg, 27%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07880013B2
Source dataset	uspto-grants-2011_02
ORD ID	ord-6744ca03c4f24fc7bf913d8a3bcd259f
Source note	uspto-grants-2011_02