1,2-Ethanediamine, N1,N1,N2-trimethyl- → HCID 23144631, compound

Participants

Reaction Conditions

Reaction Steps

Compound 107 (150 mg, 0.387 mmol) was dissolved in N,N,N′-trimethylethylenediamine (1 mL), followed by stirring at 60° C. for 4 hours. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified through silica gel column chromatography (chloroform:methanol=20:1) and then crystallized from diisopropyl ether to afford the entitled Compound 109 (70 mg, 40%) as a white solid.

Provenance & Evidence