Methanol → HCID 23144098, compound

HRID 1361814Notes

Reaction equation

HRID 1361814 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[S:9][C:10]=1[CH:11]([OH:20])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][N:13]=1.CO>ClCCl>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:26])([CH3:25])[CH3:27])[S:9][C:10]=1[C:11]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][N:13]=1)=[O:20]

Participants

4

Reactant 2

HCID 887MethanolHCID 23144587HCID 23144587, compound

Product 1

HCID 23144098HCID 23144098, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 296 (697 mg, 1.73 mmol) was dissolved in dichloromethane (10 mL), and DMP (848 mg, 2.00 mmol) was added thereto, followed by stirring at room temperature for 1 hour. Methanol (10 mL) was added to the reaction mixture, followed by stirring for 10 minutes, and the solvent was distilled away under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane:ethyl acetate=1:1) to afford the entitled Compound 297 (632 mg, 91%).

Workup

  1. additionDMP (848 mg, 2.00 mmol) was added
  2. stirringby stirring for 10 minutes
  3. distillationthe solvent was distilled away under reduced pressure
  4. customThe resulting residue was purified through silica gel column chromatography (hexane:ethyl acetate=1:1)

Sources & evidence

ORD record
ord-da554908e43e42f095b6e52e041e9159
Source dataset
uspto-grants-2011_02
Patent number
US07880013B2

Reaction notes

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