HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloropyridine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloroisonicotinic acid | HCID 236985 | — |
| Product | 2-Chloropyridine-4-carbonyl chloride | HCID 2800003 | — |
Reaction Steps
2-Chloroisonicotinic acid (707 mg, 4.49 mmol) was suspended in thionyl chloride (10 mL), followed by stirring under heating and reflux for 7 hours. The reaction mixture was concentrated under reduced pressure to afford 2-chloroisonicotinoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07880013B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-691133f9543c438bae459ad49fd98588 |
| Source note | uspto-grants-2011_02 |