反应详情

The title compound was prepared by following the procedure for example 1, except that the reagent (2R)-6-hydroxyhexane-1,2-diyl dinitrate was replaced by (2R)-3-(2-hydroxyethoxy)propane-1,2-diyl dinitrate (intermediate 5), and 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid was replaced by 4′-[(1,7′-dimethyl-2′-propyl-1H,3′H-2,5′-bibenzimidazol-3′-yl)methyl]biphenyl-2-carboxylic acid. 1H NMR (300 MHz, CDCl3) δ 7.85 (m, 2H), 7.60-7.20 (m, 12H), 6.74 (q, 1H), 5.48 (s, 2H), 5.35 (m, 1H), 4.77 (m, 1H), 4.58 (m, 1H), 4.24 (t, 2H), 3.84 (s, 3H), 3.72 (m, 4H), 2.96 (t, 2H), 2.79 (s, 3H), 1.91 (m, 2H), 1.27 (d, 3H) 1.08 (t, 3H).