Methanol → HCID 178441693, compound

Participants

Reaction Steps

A methanol (5 mL)/dichloromethane (5 mL) solution of 1-{[(5R)-5,6-bis(nitrooxy)hexanoyl]oxy}ethyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate (713 mg, 0.756 mmol) was heated by microwave irradiation (120° C., 10 minutes). Purification of the reaction mixture by reversed-phase mass-directed high-performance liquid chromatography afforded the title compound. Chromatography of the diastereomeric mixture over Chiralpak AD-H, eluting with methanol/carbon dioxide, afforded the separate diastereomers.

Provenance & Evidence